WebAug 10, 2024 · BMAL1 overexpression promoted cell proliferation and migration. Mechanistically, we found that BMAL1 may activate the epithelial-to-mesenchymal transition (EMT) pathway and induce the β-catenin release further promotes the expression of oncogene c-Myc and the migration of colorectal cells by activating MAPK pathway. … WebFeb 20, 2024 · As shown in Fig. 5E and F, BMAL1 overexpression attenuated p53 expression as well as cell autophagy. The p53 overexpression augmented autophagy, …
Restoring the dampened expression of the core clock molecule BMAL1 …
WebApr 6, 2024 · The successful knockdown and overexpression of Bmal1/Per2 were detected by fluorescence microcopy. Flow cytometry found out that Bmal1 or Per2 knockdown resulted in G1-phase cell cycle arrest. RT-qPCR showed the different expression levels of Wnt-3a, c-myc1 and axin2 in the Wnt/β-catenin signaling pathway as well as the gene … WebNov 16, 2024 · However, BMAL1 overexpression obviously increased the modified Garcia scores after ICH . A Morris water maze was carried out from 21 to 26 days after ICH to evaluate cognition and further confirm whether upregulation of BMAL1 by overexpression attenuated brain injury in rats after ICH. More serious cognitive dysfunction was … albizia medi herb
Bmal1 regulates inflammatory responses in macrophages by
WebThe major findings of the present study were as follows; i) overexpression of both Clock and Bmal1 simultaneously inhibited cell growth, ii) the mechanism of slow cell growth was an inhibitory effect of these two genes on entry from the G1 phase to the S phase at cell cycle level, iii) in the Clock and Bmal1 overexpressed cells, CyclinD1 was ... WebMay 5, 2015 · Importantly, overexpression of phosphorylation-competent BMAL1 in MCF7 cells increased the number of metabolically active cells while the phosphorylation-incompetent BMAL1(S42G) had no significant effect . The effect of BMAL1 on proliferation was dependent on the presence of serum. WebMar 21, 2024 · We have shown that 1) loss of Rev-erbα in mice exacerbates P. acnes-induced skin inflammation, a phenotype similar to that of Bmal1-/-mice, 2) Rev-erbα silencing attenuates the inhibitory effects of Bmal1 overexpression on the expression of the pro-inflammatory factors Cxcl1, IL-1α and IL-6, and 3) Bmal1 knockdown fails to alter … albizia meerstammig