Cryptotanshinone stat3

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August undefined, 2024

WebAug 9, 2024 · Cryptotanshinone (CT) effectively inhibited glucose uptake and lactate production in ovarian cancer cells. CT exerted its anti‐tumor effect by targeting STAT3/SIRT3/HIF‐1α signaling pathway in vitro and in vivo. CT may be developed as a chemotherapeutic agent to treat ovarian cancer. Go to: 1. INTRODUCTION WebMay 11, 2024 · Cryptotanshinone inhibits human glioma cell proliferation in vitro and in vivo through SHP-2-dependent inhibition of STAT3 activation Download PDF Your article has downloaded

Cryptotanshinone inhibits proliferation yet induces apoptosis by ...

WebCryptotanshinone can induce the apoptosis of cancer cells by inhibiting PI3K/AKT, STAT3 signaling pathways, as well as transcription of MMP14, STAT3, and Nrf2 genes. The arrow represents the upregulation, and the T area represents the downregulation. Conclusion WebLung cancer is a malignant tumor characterized by a rapid proliferation rate, less survivability, high mortality, and metastatic potential. This review focuses on updated research about the clinical application of traditional Chinese medicine (TCM) as an adjuvant therapy to lung cancer treatment and the mechanisms of TCM effect on lung cancer in … darks clouds

Cryptotanshinone induces cell cycle arrest and apoptosis through …

WebAug 9, 2024 · Cryptotanshinone (CT) is isolated from the plant Salvia miltiorrhiza Bunge and has been identified to block STAT3 phosphorylation and homodimerization. 7, 8, 9 CT has … WebCostunolide, an active sesquiterpene lactone, is derived from several medicinal plants, such as Saussurea lappa Decne and Laurus nobilis L. Jin et al. showed that costunolide inhibited osteosarcoma growth and metastasis by suppressing STAT3 activity . Cryptotanshinone, an active quinoid diterpene, can be isolated from Salvia miltiorrhiza Bunge ... WebMay 11, 2024 · Cryptotanshinone suppresses the proliferation and induces the apoptosis of pancreatic cancer cells via the STAT3 signaling pathway. Mol Med Rep 2015; 12 : 7782–7788. Article CAS Google Scholar darks coffee

Comprehensive live-cell imaging analysis of cryptotanshinone …

Apoptosis Induced by Tanshinone IIA and Cryptotanshinone Is ... - Hindawi

WebCryptotanshinone rapidly inhibited STAT3 Tyr705 phosphorylation through a JAK2-independent mechanism. Cryptotanshinone selectively inhibits STAT3-activated cell lines … WebDec 31, 2008 · Cryptotanshinone binds to STAT3 monomer and inhibits the dimerization of STAT3. To visualize cryptotanshinone inhibition of STAT3 localization in intact cells, … bishop robert barron winona rochesterWebCryptotanshinone is a major tanshinone that exhibits multiple activities. Exhibits antitumor activity via inhibition STAT3 activity (IC 50 = 4.6 μM). Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMPK (AMP-activated protein kinase). bishop robert barron richard rohr

"WebCTS is a cell-permeable diterpene quinone and its chemical name is 1,2,6,7,8,9-hexahydro-1,6,6-trimethyl- (R)-phenanthro (1,2-b)furan-10,11-dione (CAS registry number: 35825-57-1), with a molecular formula of C 19 H 20 O 3, a molecular weight of … " - Cryptotanshinone stat3

Cryptotanshinone stat3

Cryptotanshinone, a Stat3 inhibitor, suppresses colorectal cancer ...

WebCryptotanshinone induces cell cycle arrest and apoptosis through the JAK2/STAT3 and PI3K/Akt/NFkB pathways in cholangiocarcinoma cells. Background: Cholangiocarcinoma …

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WebFeb 5, 2024 · Background Several studies have highlighted both the extreme anticancer effects of Cryptotanshinone (CT), a Stat3 crippling component from Salvia miltiorrhiza, as well as other STAT3 inhibitors to fight cancer. Methods Data presented in this experiment incorporates 2 years of in vitro studies applying a comprehensive live-cell drug-screening … WebMay 27, 2024 · EPT3M1-STAT3 cells (grown on coverslips) were treated with DMSO, 20 µM 323–1 or 323–2, 100 µM S3I-201, or 5 µM cryptotanshinone for 24 h. Cells were fixed with 4% paraformaldehyde, …

WebJan 14, 2024 · A positive combination effect between cryptotanshinone and senkyunolide I, two representative compounds from the two GXNT herbs, was identified in the regulation of thrombogenesis, which possibly functions through mediating oxidative stress, platelet activation and coagulation cascade. WebMay 1, 2024 · Studies on the molecular mechanisms underlying the activities of cryptotanshinone have established that the JAK2/STAT3, PI3K/AKT, NF-κB, AMPK, and cell cycle pathways are involved in the inhibitory and pro-apoptotic effects of cryptotanshinone on different tumor cell lines, these molecular pathways interact in a coordinated manner …

WebJun 6, 2013 · Cryptotanshinone inhibits STAT3 phosphorylation by binding to the SH2 domain, inhibiting nuclear translocation, and binding to its target genes for transactivation (Lu et al., 2013). Treating the ... WebSTAT3 inhibitor (IC 50 = 4.6 μM). Cell-permeable, naturally occuring constitutent of Salvia miltiorrhiza with diverse biological activities. Shows anticancer, antibacterial, anti …

WebJan 4, 2024 · Cryptotanshinone is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC50 of 4.6 μM. Properties Articles 39 Spectrum Names Cryptotanshinone Biological Activity Chemical & Physical Properties MSDS Cryptotanshinone MSDS (Chinese) Safety …

Webanticancer therapy, that promotes the binding of signal transducer and activator of transcription 3 (STAT3) to Cryptotanshinone has been investigated. This binding tremendously reduces both the cellular production of STAT3, and the availability of the STAT3 dimers that drive production of various cellular oxygen and electron sources [11]. bishop robert barron interview sheaWebOct 27, 2024 · A new synthetic derivative of cryptotanshinone KYZ3 as STAT3 inhibitor for triple-negative breast cancer therapy Silencing STAT3 is confirmed as a promising therapeutic strategy for triple-negative breast cancer (TNBC) therapy to address the issue of its poor prognosis. darks corner storeWebCryptotanshinone. 本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。 ... Cryptotanshinone是一种STAT3抑制剂，在DU145细胞中能显着阻断STAT3 Tyr705磷酸化，但不能阻断STAT3 Ser727磷酸化，并显着抑制JAK2磷酸化，IC50为?5μM，而不影响上游 ... darks corporationWebCryptotanshinone Inhibits STAT3, but Not STAT5, Signaling in K562 Cells Parallel assays were carried out in cryptotanshinone-treated K562 cells. Different from tanshinone IIA, cryptotanshinone reduced the phosphorylation level of STAT3, but not STAT5, in a dose- and time-dependent manner (Figure 3 (a) ). dark scorpion water filter 14mmWebCryptotanshinone inhibits STAT3 signaling to alleviate cardiac fibrosis in type 1-like diabetic rats. Phytother Res. 31(4): 638 – 646. , , [Web of Science ®], [Google Scholar] Longa EZ, … darks cornerWebSep 29, 2024 · Pyrotinib specifically targeted TSC2-deficient cells, inhibited tumor cell viability and induced apoptosis through EGFR-STAT3/CD24 Loop in vivo and in vitro. Thus, pyrotinib may be a promising new therapeutic drug for TSC treatment. ... Similarly, cryptotanshinone induced significant early and late apoptosis in TSC2-deficient cells, but … dark scotch alWebApr 26, 2015 · Cryptotanshinone suppresses Stat3 phosphorylation in colorectal cancer cells. HCT116 and SW480 cells were seeded as 2 × 10 4 in 100-mm plates and after 24 h were treated with 0.1 % DMSO, 5, 10, 25, or 50 µmol/L CPT. After 24 h of treatment, extracts were analyzed by Western blotting analysis. a, c Total and phosphorylated Stat3. dark scorpions yugioh