WebIRF1 has been shown to have a range of different biological functions, including the promotion of systemic inflammatory responses, augmentation of LPS-induced oxidative stress and the expression of the immune checkpoint PD-L1 in the tumor microenvironment [1, 3]. NF-κB and IRF signaling pathways in THP1-Dual™ KO-IRF1 cells More details Webb Western blot assay detecting IRF1 protein expression in CD11b + myeloid cells sorted from intestines of DSS-treated Carinh WT and Carinh KO mice (n = 3). c – e DSS-induced …
MYC activation impairs cell-intrinsic IFNγ signaling and confers ...
WebNov 26, 2024 · Cell viability was 95% for all culture conditions. As a control, we also determined the half-life of c-myc (n = 3). b Similar experiment to that in (a), but LPS was used instead as the Mda5 activator (n = 3). c BMDMs from Stat1 knockout mice and the corresponding wild-type counterparts were isolated and stimulated with IFN-γ, IFN-α, or … WebApr 11, 2024 · In all cells, around one-fifth of the regions that recruited IRF1 were within or near gene promoters, indicating that IRF1 was enriched in these regions (Figure 4 B). There were fewer (half or less) IRF1-bound regions in the part-R (H23 and H82) and non-R (H1993 and PDC11) cells, compared with the comp-R cells (A549 and Lu165). greene county senior citizens fund
NF-κB–dependent IRF1 activation programs cDC1 …
WebNov 15, 2008 · Most importantly, IRF8 directly regulates the expression of EBF and PU.1, thereby defining novel aspects of the transcriptional regulatory network for specification … WebIRF1 Available structures PDB Ortholog search: PDBeRCSB List of PDB id codes 1IF1 Identifiers Aliases IRF1, IRF-1, MAR, interferon regulatory factor 1 External IDs OMIM: 147575MGI: 96590HomoloGene: 1658GeneCards: IRF1 RNA expressionpattern Bgee Human Mouse(ortholog) n/a Top expressed in jejunum duodenum corneal stroma large intestine … WebThe present findings suggest that IRF1 is associated with metastasis and the degree of immune infiltration of CD8+ T cells (general), dendritic cells, T-helper 1 cells, and T cell exhaustion in COAD. These results may provide information for immunotherapy in colon cancer. 1 Introduction greene county sewer bill