WebAug 7, 2024 · Jeffrey L. Cummings, MD, ScD: Currently, although psychosis is a common problem in Alzheimer disease and other dementias, there are no approved therapies for the treatment of psychosis in dementia. The HARMONY trial of pimavanserin treatment of dementia-related psychosis was a unique trial, both in terms of its design, but also in … WebSep 2, 2024 · In the 12-week open-label period, pimavanserin treatment showed a sustained reduction of psychotic symptoms. In the 26-week double-blind period, patients on …
Journal Club - Trial of pimavanserin in dementia-related …
WebJul 22, 2024 · As published in The New England Journal of Medicine, pimavanserin (Acadia Pharmaceuticals; San Diego, CA) treatment made relapse of dementia related psychosis (DRP) almost 3 times less likely.Results of the phase 3 HARMONY study (NCT03325556) of pimavanserin for DRP were so clearly showed efficacy that the trial was stopped early so … WebJul 23, 2024 · Acadia Pharmaceuticals has announced that the FDA has accepted its supplemental new drug application (sNDA) for pimavanserin (Nuplazid) for the treatment of hallucinations and delusions associated with dementia-related psychosis (DRP). 1. The sNDA is supported by the results of the phase 3 HARMONY study (NCT03325556), in … plasterers cornwall
New treatments for psychosis in Alzheimer’s disease - pimavanserin …
WebJul 22, 2024 · The serotonin-receptor modulator pimavanserin reduces psychosis in patients with Parkinson’s disease. In a randomized discontinuation trial involving patients with psychosis related to several ... WebAug 11, 2024 · In July, 2024, the manufacturer of pimavanserin sought a wider licensing indication for the treatment of dementia-related psychosis. This approach is based on the assumption that the symptoms of psychosis seen in patients with any dementia diagnosis, regardless of the underlying neuropathology, will respond to the same pharmacological … WebThe U.S. Food and Drug Administration today approved Nuplazid (pimavanserin) tablets, the first drug approved to treat hallucinations and delusions associated with psychosis … plasterer looking for work