Sleep phenotypes

Author: swza

August undefined, 2024

WebMar 10, 2024 · The rationale for the classification we used is as follows: High amounts of full wakefulness is interpreted as having low sleep pressure over a large fraction of the study, while very low amounts of full wakefulness across the sleep period suggests that sleep was not fully restorative. WebObstructive sleep apnea (OSA) is a complex and heterogeneous disorder and the apnea hypopnea index alone can not capture the diverse spectrum of the condition. Enhanced …

Genetic determinants of daytime napping and effects on ... - Nature

WebMar 15, 2024 · 1 INTRODUCTION. Obstructive sleep apnea (OSA) is recognized as a complex and heterogeneous syndrome, with different aetiology, 1, 2 predisposing factors, … WebMar 3, 2024 · Human sleep phenotypes can be defined and diversified by both genetic and environmental factors. However, some sleep phenotypes are difficult to evaluate without … or5t2

Effects of poor sleep on the immune cell landscape as assessed ... - Nature

WebJun 4, 2024 · The gene responsible for the mutant phenotype encodes an integral membrane protein whose loss in neurons, including in peptidergic subpopulations, reduces sleep by increasing accumulation of undigested autophagosomes. Genetic manipulations that block autophagy upstream of Atg8 recruitment to autophagosomes suppress the aus … WebWhile there are some small studies of ‘omics and sleep phenotypes, they are often reported on a small study population, and in experiments. Such studies are very important, because … WebJun 16, 2024 · In this study, we leveraged two-sample Mendelian randomization (MR) analyses to assess the causal associations of self-reported daytime napping, daytime sleepiness, and other sleep phenotypes with cardiometabolic diseases including ischaemic stroke (IS), coronary artery disease (CAD), heart failure (HF), and Type 2 diabetes mellitus … or5726

The 103,200-arm acceleration dataset in the UK Biobank …

Self-reported daytime napping, daytime sleepiness, and other sleep …

WebAlthough obstructive sleep apnea (OSA) is associated with metabolic disorders, it is unclear whether there is an association between HTGW phenotype and OSA. Methods: We enrolled consecutive participants presenting to a sleep center in Shanghai, China. Full-night polysomnography was performed, and serum triglyceride (TG) levels and waist ... WebMar 15, 2024 · 1 INTRODUCTION. Obstructive sleep apnea (OSA) is recognized as a complex and heterogeneous syndrome, with different aetiology, 1, 2 predisposing factors, 3 clinical presentations, 4, 5 and comorbidities. 6 Currently, overnight polysomnography (PSG) remains the gold standard for the diagnosis of OSA. 7 The assessment of its severity and … portsmouth nh economic development directorWebA sleep spindle is a rapid burst of higher frequency brain waves that may be important for learning and memory (Fogel & Smith, 2011; Poe, Walsh, & Bjorness, 2010). In addition, the appearance of K-complexes is often … portsmouth nh downtown

"WebAbout 25-50% of children and adolescents with attention-deficit hyperactivity disorder (ADHD) experience sleep problems. An appropriate assessment and treatment of such … " - Sleep phenotypes

Sleep phenotypes

Anatomical phenotype of obstructive sleep apnea …

WebMar 30, 2024 · Hyper- and hypo-arousable phenotypes exceeding two standard deviations from the mean are highlighted (data in Tables S1 and S2 ). Data were normalized for spontaneous arousals from sleep, and negative values are seen when spontaneous arousals are more frequent than arousals after stimulation. WebMar 22, 2024 · SignificanceHuman sleep phenotypes are diversified by genetic and environmental factors, and a quantitative classification of sleep phenotypes would lead to the advancement of biomedical mechanisms underlying human sleep diversity. To achieve that, a pipeline of data analysis, including a state-of-t …

Did you know?

WebJul 10, 2024 · More importantly, feeding the mice with sodium butyrate reversed the CypD-associated mitoflash phenotypes and protected against ectopic upregulation of CypD, unveiling a novel molecular mechanism underlying butyrate mediated alleviation of ALS progression in the mouse model. Mitoflashes are spontaneous transients of the … WebApr 4, 2024 · Sleep variables included AHI, percent sleep time SpO2<90%, Epworth Sleepiness Scale (ESS), Women’s Health Initiative Insomnia Rating Scale (WHIIRS) score, …

WebMar 27, 2024 · In a recent study, we quantified well over 300 sleep-related phenotypes in a genetic reference population (GRP) of mice 5. These phenotypes included time spent in the various sleep-wake states, their distribution over the day, and the frequency- and amplitude-specific characteristics of the electroencephalogram (EEG), all under undisturbed ... WebAbstract. Human sleep phenotypes can be defined and diversified by both genetic and environmental factors. However, some sleep phenotypes are difficult to evaluate without …

WebThe outcomes used in phenotype identification should be carefully defined, given that some features such as excessive daytime sleepiness, sleep fragmentation, or treatment … WebAug 26, 2024 · By contrast, sleep is a multidimensional phenotype. It can include, for example, sleep duration and timing, but also the spectral power of electroencephalograph (EEG) signals at particular...

WebFeb 19, 2024 · Sleep phenotype (also known as chronotype) refers to an observable pattern of behaviors with genetic links, in this case, tendencies toward earlier bedtimes and …

WebJun 16, 2024 · In addition to summary statistics for cohort and time-of-day (wake vs. sleep hours), data were parsed (i) by cosinor analysis to obtain the rhythmic parameters amplitude and phase, (ii) by two-way ANOVA analysis and post hoc Tukey test corrected for multiple testing with the Benjamini–Hochberg method to discover significant associations, and ... or500lcdrm1u rackmount lcd series upsWebFeb 18, 2024 · Across two independent samples of adults (N 1 = 4600; N 2 = 2598) from the Midlife in the United States Study, latent class analysis (LCA) extracted sleep phenotypes using five key self-reported sleep dimensions.Log-binomial regression was used to determine whether sleep phenotypes differentially predicted cardiovascular conditions, … portsmouth nh downtown restaurantsWebThe Importance of Sleep Phenotypes in Bipolar Disorders Bipolar and Related Disorders JAMA Psychiatry JAMA Network Sleep disturbance plays several key roles in bipolar disorder (BD). From a diagnostic perspective, insomnia and hypersomnia are criteria for a depressive episod [Skip to Navigation] or56a1